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Re: Judith's comment: >> I am taking sinemet CR and often >> find it takes as much as an hour and a half to feel the effects, though I >> was told it should not take that long. >> Regards, Judith. I too find ( Since I came off Eldepryl) that it takes about one and a half hours for sinemet CR to "kick in" in the morning and on a bad day even 2 hours. Fortunately for me, as I am still only fairly recently diagnosed, I can normally "Get through" the off period. If I could not, I would suggest Joe's "trick" to my neurologist. Joe's "trick" is copied below. >Alan, try the second trick I mentioned- if your dr. approves the extra >dosage: Half a regular 25/100 tablet gets me started before breakfast. >After a half hour it has taken effect and then I can eat; then about >an hour after breakfast (2 hours after the first dose) I take the >50/200 CR which lasts the rest of the morning. You might wish to look >up a new citation, which will appear in the June 1996 CSR, describing >the trick: Pahwa R et al; Neur 1996;46:1059-1062 Regards to all, Ernie Peters ([log in to unmask])