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Nancy Perry and numerous others including me have mulled over the toxic environmental exposure as cause theoretical postulated rather than genetic. The studies by many have been inconclusive. There are some significant statistical correlations and some family genetic defects. Upon noting many of us recalling personally traumatic periods just before symptoms (Nancy's husband must have been very apprehensive about prostate cancer surgery) and I was very depressed following the automobile killing my daughter. Perhaps PD and AD (my mother developed symptoms during her depression occasioned by the death of my father due to infection complications following concurrent ulcer and bypass surgery post his heart attack) and other neural net (brain) diseases are correlatable to (brought on - manifested by) sustained mental anguish/depression. Zero zest for life or suicidal feelings may trigger cognitive apoptosis of the whole neural network. The brain's immune system in depression state for too long may self-destruct in one of these dis-ease syndromes. Forgetting the unpleasant emotional woes that cognition is occupied with may induce forgetting - loss of short term memory is manifest after the brain has been attempting to suppress memory of bad emotional events and/or emotional fear about the future. ron 1936, dz PD 1984 Ronald F. Vetter <[log in to unmask]> http://www1.ridgecrest.ca.us/~rfvetter/