My wife took amantadine briefly a few years ago. She was taking Sinemet at the time, and amantadine was supposed to enhance its effect. It was not of help, and it had no bad side effects. She took artane for 2 or 3 years around 1990, at which time she had had PD for about 3 or 4 years. It ultimately affected her sensorium so badly - delusions, disorientation, etc. - that it had to be discontinued. Best regards Bob Howard Bob Howard, occasionally knowm formally as: Robert B. Howard 1320 Wisconsin St., Apt. 411 Hudson, WI 5401 CG for Lorraine 76/10+ e-mail <[log in to unmask]> New address as of 5/3/96 Voice phone: (715) 386-3596 FAX: (715) 386-8589 Manual reception, requires phone call.