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Date Mon 13 May 12.30am Reply to: Steven E. Mayer Subject: Doses of Pergolide I have been using Pergolide combined with around 1000mg of Pergolide for 18 months. Until recently I have used 4 x 250 micro gm per day and according to my calculations this gave me an additional 'headroom' of about 15 mg/hr of Levodopa. By this ,I mean that I gained that much extra margin before unpleasant levels of dyskinesia were encountered. For the last month I have been taking a total of 6 x 250 micro gm Pergolide with again a noticeable improvement in headroom. Perhaps the best aspect of the drug is that unlike Levodopa, Pergolide appears to have a long residence time in the brain, and reduces the sensitivity to meals, which was beginning to dominate the situation. I am relieved to say that I have not encountered any side effects at the present dosage levels. I sould say that I was diagnosed as having PD 16 years ago, and have been using levodopa for the past 13 years. I generally expect to have about 1 to 2 hours Off per day, otherwise I manage fairly well. Regards, Brian Collins ( [log in to unmask] )