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Ernie Peters wrote: > > Re: Judith's comment: > > >> I am taking sinemet CR and often > >> find it takes as much as an hour and a half to feel the effects, though I > >> was told it should not take that long. > >> Regards, Judith. > > I too find ( Since I came off Eldepryl) that it takes about one and a half > hours for sinemet CR to "kick in" in the morning and on a bad day even 2 hours. > > Fortunately for me, as I am still only fairly recently diagnosed, I can > normally "Get through" the off period. If I could not, I would suggest > Joe's "trick" to my neurologist. Joe's "trick" is copied below. > > >Alan, try the second trick I mentioned- if your dr. approves the extra > >dosage: Half a regular 25/100 tablet gets me started before breakfast. > >After a half hour it has taken effect and then I can eat; then about > >an hour after breakfast (2 hours after the first dose) I take the > >50/200 CR which lasts the rest of the morning. You might wish to look > >up a new citation, which will appear in the June 1996 CSR, describing > >the trick: Pahwa R et al; Neur 1996;46:1059-1062 > > Regards to all, > > Ernie Peters ([log in to unmask])Hello to all, Thought I would jump in and add my experience. The neuro that started me on Sinemet CR had me take 1 1/2 tabs in the morning. The theory being that the extra 1/2 was needed to help me get started, and that, by breaking the tab in half, it allowed the medication to be released quicker than if it was whole. It has worked pretty well for me, but mornings are usually still the most difficult time of the day. SOON! Gaylon