Hi again: I am following up my previous Smoking and Parkinsons article with another exceprt from a related article from newhope (www.newhope.com). This time melatonin is described as reducing the previously mentioned hydrogen peroxide. Ron Reiner ([log in to unmask]) 48 + 9mos --------------------------------------------------------------------------- Melatonin Melatonin is a hormone produced by the brain in abundance throughout early life but to a lesser degree in elderly years. It helps to keep the body in sync with circadian rhythms--the rhythms of the day and the seasons of the year. As well as being known as a sleep aid and a help for jet lag, recent studies suggest that supplemental melatonin is also a powerful brain antioxidant that may help people to retain their cognitive functions. Due to its high fat content, the brain is particularly susceptible to attack by free radicals, and it appears that melatonin is more effective than vitamins C and E in neutralizing these scavengers. [This is the good part! Ron] It also stimulates the primary antioxidant enzyme in the brain, glutathione peroxidase, which converts destructive hydrogen peroxide (H202) into benign water (H20).1 According to one researcher who has done extensive studies on melatonin, "we are currently working under the assumption that melatonin evolved coincident with aerobic metabolism to specifically protect cells and organs from the resulting oxidative attack by oxygen-centered radicals."2