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David, Just read your post on the Sinemet holiday you took. My neurologist thinks my Sinemet CR may be contributing to my nausea this last week. I've taken less, one-half Sinemet CR, 50/200 at seven a.m. and the other half at12:30. then half at five or six o'clock. I'm still feeling sick and very dizzy/light-headed. Would you recommend a test of even less Sinemet with what you experienced? The Sinemet CR has lessened my tremor and gotten rid of some stiffness but this stomach problem is tough too. I hate this stuff(PD), I know---all I can change is my attitude towards it. Well, I hate it. I'm trying but I seem to have a bad attitude. Thanks, Patricia 59,one year plus [log in to unmask]