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Patricia Sorry. I wish I could help but I can't. I'm no expert on drugs--I was describing a personal experiment not yet finished and the results good or bad may not relate generaly.Unlike you I have not had a bad experience with Sinemet and no nausea --I was merely concerned about the wearing off effects.There are many on this list who have a lot of experience about the effects of Sinemet and ways of avoiding nausea and hopefully somebody will come up with a suggestion. Good luck David Langridge. PS Since writing this I have opened my mail and see that Alen Bonander has sent a message on Sinemet and Nausea which tells you all you want to know and more.Just goes to show what a good list this is.