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Just another anectdotal example of how different we all are, and how PD (and its medications) affect us: Dad (68/4+) takes Sinemet CR -- with food. Otherwise he ends up with far too much in his system. He has no true on/off periods, although mornings are better than later in the day. No insomnia, either. Now, if we could just do something about his stubborn streak (not PD related)! Incidentally -- Dad came home Friday after 3 wks in the hospital for his bruised hip. Thanks again to all who answered my questions. Diane McHutchison email - [log in to unmask]