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TO: Stephen C. Holahan I have been taking 25 mg amitriptyline for 9 years at night. I remember it was listed in the APDA pamphlet then and probably still is. In fact, I started taking it about a full year before I started sinemet. It apparently helps things other than depression. I found it helped my tremor and at least as importantly to me, it helps my ongoing neck pain. I have heard recently of other cases of chronic pain where up to 75 mg is being used for pain management. I believe I've heard (but you can check w/ a doctor) that for depression dosages are more in the 150 mg range. As far as sleep, I have generally had no sleep problems. (Also, I try not to take sinemet after 6 or 7 p.m.) Hope this info is of some help. Barbara Blake-Krebs [log in to unmask]