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Thanks to everyone that sent me messages today, after I described my father's condition (59, diagnosed with PD 14 years, in wheelchair after drug holiday and difficult year, undergoing physical therapy). I am responding to your questions via the group since so many of you were nice enough to write. (Talk about a fast response!) In terms of the neurologist who recommended the drug holiday: after the holiday failed to show him anything re the medication, and after my father became physically worse, we (the family) became very frustrated with the neuroligist because he seemed all out of ideas, and seemed to be perfectly at ease with the fact that my father was now pretty immobile, and still having the paranoia (accusing my mother of trying to kill him, etc.). We finally got a referral for another neurologist--which took a while because the family doctor was associated with the former neurologist (politics are everywhere). The new neurologist has been very satisfactory. He is not a PD specialist--there are none near us--but is knowledgeable, and has also been working with a psycho-neurologist re the hallucinations and paranoia. --which brings me to my father's meds that some of you asked about: Before the drug holiday and switching of neurologists, my father was taking Sinemet, Permax, Eldepryl and Parlodel. He is now taking Sinemet (25/250) and Permax. He is also taking Zoloft and Risperdal for the psycological benefits. The new neuro didn't want to try the Clozaril (one of you asked about that) because of the hassle that goes with it i.e. blood tests, etc. In addition to the Parkinson's meds, he takes Lactulose, Zantac, Propulsid, and Coumadin (for the blood clots). Thanks again to everyone who wrote--it was much appreciated. Helene Marcy [log in to unmask]