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I subscribed briefly to this group earlier this year, and now am re-joining. My wife, who is 58, has advanced PD (onset was only 6 years ago), such that her rigidity approaches paralysis. It is probably a case of what some call Parkinson's Plus. She is not ambulatory and requires assistance with every physical activity. I have looked into pallidotomy, but the general feeling was that she would not be a likely candidate for that particular surgery, which would seem to be for the milder cases. My question is: Is fetal tissue implantation a hopeful choice for a patient with an advanced case of Parkinson's disease? Any thoughts will be appreciated. Porter Humphrey Bethesda, Maryland