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Friends--not to "beat a dead horse", but I have to confess to some confusion about the Sinemet/food connection. We have had very persuasive info from a number of people to the effect that Sinemet taken with food loses much of its value by the time it gets out of the stomach. It sounds so reasonable--then I notice that Peter's new RX bottle of Sin.CR 50/200 has a label shouting "TAKE WITH FOOD" ! So I called the pharmacist and asked about it, telling him what I had learned here. His reply was that this is the instruction from the manufacturer and the FDA requires them to so label it. He stated that the "package insert" is taken right from the PDR, which is the info supplied by the manufacturer. He could not explain it further. Now I wonder, are we correct in believing there's a problem, and that we need to wait 30-60 min. after taking it before eating? Is there something about the CR form that makes a difference in this way? (He could not find ANY info in the PDR about regular Sin. and food, only the CR form.) We would very much appreciate clarification on this issue, which is something Peter and others have to decide about many times a day! Thanks for any help you can give.(We did discuss the need for food if one is nauseated.) Camilla Flintermann,CG for Peter,78/7Oxford,OH [log in to unmask]