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Camilla, I'm unsure of this, but I think the advice against food applies only to regular Sinemet and not to Sinemet CR. I read somewhere that the half-lives respectively are 90 min and 3 hr. Maybe one of our pharmacists can clarify. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Mon, 8 Jul 1996, Camilla Flintermann wrote: > Friends--not to "beat a dead horse", but I have to confess to some > confusion about the Sinemet/food connection. We have had very persuasive > info from a number of people to the effect that Sinemet taken with food > loses much of its value by the time it gets out of the stomach. It sounds > so reasonable--then I notice that Peter's new RX bottle of Sin.CR 50/200 > has a label shouting "TAKE WITH FOOD" ! So I called the pharmacist and > asked about it, telling him what I had learned here. His reply was that this > is the instruction from the manufacturer and the FDA requires them to so label > it. He stated that the "package insert" is taken right from the PDR, which > is the info supplied by the manufacturer. He could not explain it further. > Now I wonder, are we correct in believing there's a problem, and that we need > to wait 30-60 min. after taking it before eating? Is there something about > the CR form that makes a difference in this way? (He could not find ANY > info in the PDR about regular Sin. and food, only the CR form.) We would very > much appreciate clarification on this issue, which is something Peter > and others have to decide about many times a day! Thanks for any help you > can give.(We did discuss the need for food if one is nauseated.) > Camilla Flintermann,CG for Peter,78/7Oxford,OH > [log in to unmask] >