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Alan Bonander writes: > 4. I don't know why Eldepryl is not given at lower doses. I know of many >patients that have dropped daily Eldepryl to 5 mg or less and found benefits. > The most recent Life Extension Foundation magazine has a fairly in-depth review of the widely varying studies of deprenyl (eldepryl). Life Extension has been a strong promoter of deprenyl use for a variety of situations; in light of the most recent data they have revised their recommended doses of deprenyl down to as low as 1.5 mgs per day, also allowing for a dose as high as 10 mg/day in some situations. My personal experience and evaluation of the data I have seen has been that deprenyl has a definite therapeutic value for PD patients, and I have felt for a long time that 10 mgs/day was probably overkill. As Alan pointed out, the wash out period for deprenyl is considered to be 2-3 weeks. I currently use 3-4 mgs/day of the liquid deprenyl, and am intellectually satisfied with that. I sure hope I am neuronally as happy with that choice as I am intellectually!! Kathie Tollifson [log in to unmask]