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Sydney Adams wrote: > I take Madopar 125 also known as Sinemet [log in to unmask],1@12,1@4,[log in to unmask] > Dopergine [log in to unmask],1@12,1@4,[log in to unmask] > [log in to unmask],1@12 Information that I have is that Dopergine is lisuride - NOT selegiline (this lisuride drug is available in Europe; and, is an agonist) >General tensing of body. Sleeplessness.. The taking of two selegiline hydrochloride (l-deprenyl, Eldepryl 5 mg.) in the morning and at noon is the recommended dosage by many doctors, but the drug may be a cause of sleeplessness. I have taken two for a while, but have gone back to one quite a while ago - and will use one in morning only. The general tensing of the body is IMO intrinsic to the loss of ability to relax - which is the central feature of PD as I see it. As I lose more dopaminergic cells (and take a little more medicationas time goes by), my window of best functioning - enough med to function ON but not so much that dyskinesia is significant - is harder to stay in. I have stayed with my experimental taking of half-25/250 carbidopa/levodopa twice as often. This is more trouble than pills before meals - 3 per day - or your routine of pills at 4 times per day. However, I find it works better and makes sense with the graphic addition charts that I have seen and prepared for myself and the support group. The effective amount of levodopa from regular generic carbidopa/levodopa or regular Madopar is maximum levodopa in the blood plasma about half and hour after the med reaches the small intestine. the plasma concentration drops rather rapidly - is about half the peak value in 2.5 hours. My next half pill is taken 2 to 2.5 hours after the prior one because I need to have about half the peak value of 125 mg. of levodopa to stay ON. Actually, I have now added half-0.25 mg. Permax agonist pills with my 6 halves of carbidopa/levodopa each day, plus I take a 7th half-Permax just before retiring. This additional medication was in lieu of taking a 7th half-carbidopa/levodopa which I was needing to do to stay ON and not have late afternoon foot cramps and OFF (limited to very slow and poor coordination movement). I am not informed by Syd's post whether Madopar 125 is regular or slow-release medication. I presume the two taken in am is to get a good start. If these are all slow-release meds, I would suggest one of the two be regular Madopar or generic because it will get into the blood faster - perhaps a half will do. Please recognize my opinions are not medical advice. I do advise you to learn more about how you respond to changes in medicating with your doctor's consent and monitoring - because to few take the trouble to optimize their medications regimen for minimum amounts necessary to be ON the majority of each day. Sorry these seem to all be lengthy comments. ron 1936, dz PD 1984 Ridgecrest, California Ronald F. Vetter <[log in to unmask]> http://www1.ridgecrest.ca.us/~rfvetter