There was a note here recently from someone who decided to take most of his protein foods at suppertime - keeping breakfast and lunch low on protein and high in carbohydrates so that his Sinemet (carbidopa/levadopa) would work better during the day when he works. This worked - however he noted that he had difficulty sleeping at night and had leg cramps. This kind of distribution of protein has bothered some people. Especially those of us who have restless legs syndrome. Evening and nightime are difficult to downright painful. Whilst trying to relax, read, or sleep, the twitching creepy feeling starts in the legs (and sometimes arms). It is pure torture. It is difficult to explain the feelings of crawling, creeping, pulling, tingling and twitching beneath the skin. Sinemet seems to help but it can't get past the protein eaten at suppertime. I am getting relief at the moment by eating all the day's protein before 3 p.m. and then switching to vegetable salads and fruit for the rest of the day. If I adhere to this regimen I can get a fairly good night's sleep after a pretty decent evening without leg twitches and severe muscle pains. If I go out for an evening of steak or ribs or fish I am in trouble. I will be awake all night walking and doing stretching exercises or soaking in a hot tub. My husband will massage my legs with cold and hot liniments. Unfortunately these remedies are short lived and you promise yourself "no more protein after 3 p.m." If you have this problem with protein and try to overcome the disagreeable leg restlessness by taking more and more Sinemet at night, expect a rebound reaction in the a.m. eventually. You will probably wake up with twitching restless legs and then take more Sinemet for relief and a vicious cycle sets in. I wonder if many people with PD have this problem with protein? I'd like to hear from Kathrynne Holden RD on this. She explains nutrition for Parkinsonians so well. Thanks for your valuable input. Barbara Yacos RN <[log in to unmask]>