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Robert Graham: You are right in that the PDR states that there is a potential interaction called "Serotonin Syndrome" that can result when eldepryl is taken with a SSRI, a TCA or lithum or tryptophan. SSRIs are Prozac, Zoloft, Paxil, Serzone, Effexor, Wellbutrin, Desyrel. TCA are Elavil, Tofranil, Pamelor, Norpramiln, Sinequan. Serotonin Syndrome Symptoms: Motor sysmptoms Jerking of arms and legs Increased stiffness and rigidity Incoordination Mental behavioral symptoms: Agitation Confusion Disorientation Restlessness Miscellaneous Fever Nausea, Diarrhea Shriving, flushing Sweating Exceptional problems High fever Seizures Coma Death Now understand that not all patients taking eldepryl and an antidepressant on the list have this resonse. I for one, take 5 mg of Eldpryl and 20 mg of Paxil together daily and have no adverse reaction. I know many others who are doing similar. Please note I am taking only 5 mg daily rather than 10 mg. I do this for the following reasons: 1. I get benefit from one 5 mg tablet in the morning 2. I often forgot to take the second tablet around noon and knew that if I took it after 2 PM it would give me sleep problems, thus I didn't take it and I saw no significant change in my PD symptoms. 3. I have heard from respected sources that 10 mg daily is the "safe maximum" of an MAO-B. If 30 - 40 mg of MAO-B are taken daily, it may lose its selectivitity for B and become non-selective. Thus 10 mg daily seems to be a "safe maximum". After hearing this, I heard that recently Eldepryl was shown to have a longer half-life than orginally assumed and that most of the benefit derived from Eldepryl happens from the first 5 mg. 4. I don't know why Eldepryl is not given at lower doses. I know of many patients that have dropped daily Eldepryl to 5 mg or less and found benefits. So please understand that the potential problems with the above drugs is a warning and not a contraindication. Regards, Alan Bonander ([log in to unmask])