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Margaret, I've not had a good reaction to Tylenol, even though I don't take Eldepryl. A friend recommended two teaspoons of cider vinegar in a glass of water for foot cramps, and so far it seems to be working. I can feel the cramps coming on, so I take the vinegar then. For cramps in the calves, bite your lower lip and pinch your upper lip. Sounds crazy but it works! We are so medicated as it is that I try to avoid any extras, such as pain killers, cold medicines, sleeping pills, etc. For pain I use white willow bark (the active ingredient in aspirin), but only after the pain doesn't go away when I'm "on." I find that I often have pain, such as a headache, while I'm off," but it goes away when the meds kick in, so I'm not took quick with the pain pills. For colds and sinus problems, I stick to nasalide, a spray. Hope this helps. pine`