To Joyce Tames: ([log in to unmask] Dear Joyce: I can underestand your anger with your physician for rejecting your symptoms as reflecting a deficiency of Vitamin B/12. There certainly are simlarites in the neurological and some gastrointestinal signs. He did not seem to have substantiated his interpretations by using a large number of the several sensitive tests for an inadequate supply of the vitamin, deficient gastrointestinal absorption, etc. However, I would not reject causes other those of vitamin B/12 defiencies or even the absence of a true B/12 deficiency. For example the responses to large (multmilligram) doses of B/12 by mouth may be misleading, because this agent may have several actions other than its chief role as a vitamin. A fraction of a microgram (1/millionth of a gram)given by injection may have a persistent effect on several types of cells after a single injection. It is difficult to maintain an objective attitude in differrentiating such complex and debilitating diseases as PD and B/12 deficiencies. You need to find a neurologist and hematologist that you will learn to trust. Best wishes, Steven E. Mayer Steven E. Mayer, Ph.D.