I am on a very high daily sinemet dose: 875mg (7x125) and 1750 (7x250) Total 2625 thats a lot, but without this amount, I can't walk. In fact I often have to double up on the 125's after meals,(more sinemet) and it doesn't seem to matter what the food is: protein or other. help! I get fairly savage dyskinesia (understandably) but no other side effects. Sometimes about twice daily I have to take 1 x125 every 1/2hour usually takes about 3 x 125's to break the lock, and then it is torture while I wait to free up. The muscle tightness in the lower legs is very strong but not cramped. Has anyone any suggestions. If you say cut back the sinemet, I will need something to unlock me. I am not in a state of panic but something has to give soon !??? Perhaps I am at the end of the sinemet trail?? I know that some will say go straight to my Neuro and they are probably right; but he always agees with me about the dosage, and finds it hard to believe that I have Parkinsons, as when I go to his office, I make sure I am dosed to perfection. I am starting to see some answers to my own questions, but I will welcome your input/s thankyou for your attention kind regards from Philip Dunn Philip Dunn NORTON PC ANYWHERE FOR DIRECT CONTACT. EMAIL THE TIME TO CONNECT. [log in to unmask] Telephone number and any other information you wish to add ---