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Brian, I'm interested in your computer program and will start keeping a log of my medications today. I have just about reached the point of diminishing returns with my medications and I'm experiencing more "off/on" fluctuations than previously. I've had pd 11 years and currently take 10 CR's, 1/2 regular sinemet (10/100's to jump start in the morning) 6 pramipexole, and 5 baclafen (for distonia during the night). I'm interested in your comment that carbidopa above the level of 40-50 mg can be a problem Could you be more specific about this, since I'm taking considerably more than that? I'm also considering supplementing the CR's with regular sinemet, possibly in liquid form, to get a better response. I'm definitely feeling the need for some fine tuning! Like you, I find the dyskinesias annoying, but the "off" times are even worse, since I'm completely unproductive then. I can be going along at great speed and then suddenly come to a screeching halt. There's got to be a better way to live! Thanks for your offer. It sounds like a life raft to a drowning woman. pine`