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Have u guys tried to LIQUIDFY ur Sinemet? My neuro is a top PD researcher and this November will be one year since we switch over. I started out diluting the same dosage 10 x 25/100 in 1000CC of OJ drinking 60CC's/hour from goodmorning to goodnight. It immediately smoothed out my off dystonia. When it was obvious that I would require a much larger dosage to control my symptoms, it was decided that a "P"op was due. I did it in May and although I've been on a steady but very gradual reduction of my other meds, I am down only one 25/100 to total 9. Maybe some of this trivia will help you guys ----------------------- Hi Anne in NF After all of Alan's pleading with me to cut the CR daily doses, I pushed (suggested) to DR F that concern. He agreed and I have cut two a day = 40% WITHOUT ILL EFFECT. (I know Alan is reading and smiling at this) Joyce