hi all, the news hound is back, although a bit late. and somewhere along=20 the way, she lost the caps key again. i just struggled through an almost 'lost' weekend due to the=20 dreaded female/hormone/pd 'freeze-ups'. [i.e. when sinemet=20 mysteriously transforms itself into baby aspirin]=20 and then the recent messages about female hormones have started=20 me digging through the paterson/parkinsn archives for related=20 posts. i've got some going back to dec. 94.=20 i thought i'd post a 'summary thread' of them, since we have so=20 many new members. maybe someone out there will make a connection=20 that will lead to ...? whaddya'll think? about the 'summary thread', i mean? if it's=20 not too long? janet ps i thought these two news reports on the same subject were=20 revealing in their differences. ---------------------------------------------------------------- Post-menopausal estrogen is said to counter Alzheimer's ---------------------------------------------------------------- Copyright =A9 1996 Nando.net Copyright =A9 1996 N.Y. Times News Service=20 NEW YORK (Aug 16, 1996 2:17 p.m. EDT) -- Taking estrogen after=20 menopause may reduce a woman's risk of developing Alzheimer's or=20 delay onset of the disease, scientists said Thursday. In a study of 1,124 elderly women being published Saturday in The=20 Lancet, a British medical journal, and announced at a news=20 conference at Columbia-Presbyterian Medical Center in Manhattan,=20 researchers found that only 5.8 percent of women who had taken=20 estrogen developed Alzheimer's, compared with 16.3 percent of=20 women who had not used the hormone. With each passing year of the five-year study, only 2.7 percent=20 of the women who had used estrogen developed Alzheimer's as=20 against 8.4 percent of those who had not used it. Moreover, the=20 longer the women took estrogen, the lower their risk. Black, White and Hispanic women benefited equally from estrogen,=20 as did women with varying educational and socioeconomic levels. The findings are potentially the most promising advance ever made=20 toward the prevention of Alzheimer's disease, said Dr. Neil=20 Buckholtz of the National Institute on Aging, in Bethesda, Md.=20 "This is the third study that's shown the same kind of effect,"=20 he said, adding that it is also the best to date. Dr. Zaven Khachaturian, director of the Reagan Research Institute=20 at the Alzheimer's Association, in Chicago, said, "This study=20 opens new vistas." Researchers are not sure how estrogen might protect against=20 Alzheimer's, but studies have suggested that it helps support the=20 growth, survival and repair of nerve cells, and that it can=20 protect them from being injured by toxic substances. The research might point the way towards other compounds that=20 could delay or prevent Alzheimer's disease in men as well as=20 women, he said. "But we can't recommend that women take estrogen based on this=20 study," Buckholtz said. "Women are going to consider that, but=20 the most reasonable thing to do, with their physicians, is to=20 look at their own risks for Alzheimer's and a variety of other=20 illnesses. Estrogen does seem to reduce the risk of =20 cardiovascular disease, but it may increase the risk of breast=20 cancer. Each woman has to factor those into the risk-benefit=20 decision she's going to make." Buckholtz and the scientists who conducted the study urged that=20 further research be undertaken quickly to see if the findings=20 could be verified. In the study, a team of researchers led by Dr. Richard Mayeux, a=20 professor of neurology, psychiatry and public health at Columbia,=20 interviewed the women and asked whether they had ever taken=20 estrogen after menopause. Then, the researchers tracked the=20 women's health over the next five years and recorded how many=20 developed Alzheimer's. The study showed a strong association between estrogen use and a=20 lowered risk of Alzheimer's, but did not provide information=20 about the most beneficial doses, how long it should be taken or=20 the best formulation of estrogen. In addition, because the=20 researchers relied solely on the women's own memories of whether=20 they had used estrogen, sometimes many years in the past, the=20 figures may not be as reliable as those gathered in an experiment=20 in which patients are tracked from the moment they begin taking a=20 medication. Mayheux and his colleagues hope to answer those questions in a=20 controlled clinical trial, in which volunteer patients are assigned at random to groups that take either a known dose of=20 estrogen or a placebo, a dummy drug. "The clinical trial is the=20 gold standard," Mayheux said. A study involving 1,500 to 2,000=20 women in their 70s could probably provide the needed information=20 within five or six years, he said. Considering the known benefits of estrogen, he said, giving women=20 placebos instead of the hormone raises ethical questions. "But=20 scientifically," he said, "it's the best thing to do, and I think=20 there are still enough lingering doubts about safety that it's=20 probably worthwhile to do it." ---------------------------------------------------------------- Estrogen Therapy May Reduce Risk Of Alzheimer's Disease=20 ---------------------------------------------------------------- WESTPORT, Aug 16 (Reuters) - Results of a study published in the=20 current issue of The Lancet suggest that estrogen therapy, when=20 used by postmenopausal women for at least ten years, can reduce=20 the risk of Alzheimer's disease by 30% to 40%.=20 Dr. Richard Mayeux of Columbia University and colleagues at other=20 New York sites followed 1,124 elderly women for 1 to 5 years. The=20 group studied was initially free of Alzheimer's disease,=20 Parkinson's disease and stroke.=20 Overall, the New York team observed that 15% of the women=20 developed Alzheimer's disease, which is "...expected in a group=20 of women of this age."=20 When Dr. Mayeux evaluated only the cohort of women who took=20 estrogen therapy for at least 10 years after menopause, he=20 observed that "...a history of oestrogen use during the=20 postmenopausal period significantly delay[ed] the onset of=20 Alzheimer's disease and lower[ed] the risk of disease."=20 In a related editorial, Drs. Alistair Burns and Declan Murphy of=20 Manchester and London, UK, respectively, reported that "...sex=20 steroids modify development and ageing..." in regions of the=20 brain that deteriorate in Alzheimer's. In addition, they point=20 out that "...oestrogen is an important co-factor in the actions=20 of nerve growth factors." These actions, they suggested, may=20 underlie the mechanism of protection against Alzheimer's disease.=20 Dr. Mayeux calls for a prospective clinical trial that would=20 involve perimenopausal women.=20 Lancet 1996;348:429-432.=20 Copyright =A9 1996 Reuters Limited.=20 ------------------------------------------------------------- [log in to unmask] =20