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Hello, Phillip: I am very sorry to hear that you are suffering so much with your symptoms. In May you wrote that you had tried Permax without noticeable effects and Parlodel did not agree with you. Questions:1)have you ever tried the famous Liquid Sinemet concoction? 2) can you get either Dosinex (Cabergoline) available in Europe or ReQuip(Ropinirole) available in the UK? 3) are there any drug trials "down under" that you could hook into? One more suggestion, Brian Collins has posted an offer to help stabilize dosages via a computer program that he devised. I took him up on this offer a couple of months ago and he has been a truly valuable resource and a wonderful friend. I strongly recommend that you take advantage of his offer. Lastly, TUMS are antacid tablets, manufactured by SmithKlein Beecham. They are a good source of calcium which is the reason I have them in my medicine cabinet. Upon reading Gordon Seese's suggestion, I tried taking TUMS with my sinemet and I think it has helped!! I am a little reticent to take 9-10 Tums per day. So, I'll take them when I normally have trouble staying "on". I hope that you will have some relief SOON! Best Wishes. Margaret Tuchman You wrote: >> >Thanks for your response, but I must ask the same question what is a, or >what are, tums > [log in to unmask]