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Anne, I am commenting on the portion of your note to Bob and Philip about experiencing a better response when changing some CR to regular. My mom (82 yrs. old, diagnosed 8 years ago with PD) was on Sinemet CR for over 7 years and began experiencing a lot of fluctuation which included hours of the "off" periods and tremendous dyskinesia movement. Last March I took her to Dr. Enrico Fazzini, Assistant Professor of Neurology and Director of Parkinson's Disease & Movement Disorders at New York University Medical Center (who also has a question and answer page in the American Parksinson Disease Association's quarterly newsletter). He suggested she take a half tablet of regular Sinemet along with half a tablet of Sinemet CR three times a day, and an additional regular Sinemet in between dosages if needed. What a dramatic improvement! Unfortunately, the response differs from day to day and presently she's beginning to experience more "off" time - which I hope Dr. Fazzini will be able to help us when she visits him next month. Regards from the states, Cathy