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Bob Bowling followed Phillip Dunn, who wrote: > PD> I am on a very high daily sinemet dose...total 2625 (mgs.) PD> Thats a lot, but without this amount, I can't walk. I often PD> have to double up...after meals,(more sinemet) and it doesn't PD> seem to matter what the food is: protein or other. help! PD> I get fairly savage <dyskinesia (understandably) but no other PD> side effects..... PD> Has anyone any suggestions. If you say cut back the sinemet, I will PD> need something to unlock me.... Have you tried Pergolide or other Receptor-stimulants (I'm not sure of the medical term, but it helps the other end of the synapse where L-Dopa helps the transmitter)? Entacapone & Tolcapone are released in Europe, and are said to be good, but aren't here in UK yet, except on trials. > ... my neuro ... finds it hard to believe that I have Parkinsons, > as when I go to his office, I make sure I am dosed to perfection. I don't understand this self-defeating pride (even though I have to fight against it myself!). You want an answer? Then show yourself in your true colours! Otherwise it's like trying to explain an orgasm to an eunuch. He may understand it, if you have a good turn of phrase, but he needs to EXPERIENCE it to get the best flavour! :-) BB> ... I take 1600 mgs on an average day, 2000 on a tough day. BB> ... exercise either increases my dopamine usage, increases the BB> reuptake rate in my brain or limits the amount of dopamine precursor BB> that passes through the blood-brain barrier. I'm concerned about BB> taking too much Sinemet ... I should think you are! BB> ... and frequently try to limit daily amounts. It's a toss up which is BB> worse: too much or too little. I've studied the alternative BB> medications and discussed them with my neuro (a PD specialist with BB> a national reputation). He advises me to stick with Sinemet. But doesn't HE suggest something for the other side of the equation - a above? BB> I also consider my quarterly neuro visit a challenge and make sure BB> I'm in mid-dose at appointment time. With no offence meant, that's loco! BB> I enjoy his comment that if he didn't see so many Parkinsonians daily, BB> he might not know I'm one. You're impressing the WRONG person! BB> Both he and his nurses tell me they have a number of patients who take BB> more Sinemet than I do and get along fine. Yes, and I know people who smoke 90 cigarettes a day, but it doesn't make me happy to be a passive smoker! BB> I suspect there is a wide variance in each person's BB> "Sinemet Processing Efficiency" (new medical term--coined today). BB> Your daily 2600 mgs, my 1600 and someone else's 400, after processing BB> by our bodies, could result in the same net "Medicinal Value" Yes, but the number of factors involved is HUGE: activity rate, body weight, metabolic rate, diet, environmental factors, stress, number of people around one, etc. etc. I loved your science fiction monitor idea, but regret that's what it is! :-) -- Jeremy Browne, Hampshire, UK [log in to unmask] Shaking Hands BBS, Fidonet 2:252/160 (+44 1252 621745)