>>HEllo readers: >>I'm aware that Emory is actively engaged in the new antiparkinson drug >>trial of Tolcapone, and that it is already being used in Europe. >>Tolcapone, a COMT inhibitor, supposedly works on patients experiencing >>stable response to L-dopa. It prolongs the elimination of L-dopa, >>therefore allowing it to work for a longer period of time. >> >>I'm wondering if anyone on the network uses Tolcapone? >> >>If anyone does, I would be interested in knowing what the standard dosage >>is in Europe? And what side effects there are with this drug? Or anything >>else? >> >>Please let me know by noon tomorrow, if possible. >>Thanks, >>Millie SEaman > > >Millie > >>Extract from previous posting from Ernie Peters giving extract from article >by Professor Jenner > >Two drugs for potentiating the effect of L-DOPA are under development. >These compounds, called Entacapone (Orion, Finland) and Tolcapone >(Hoffmann-LaRoche, Switzerland) act by preventing the breakdown of L-DOPA by >an enzyme called catechol O-methyl transferase (COMT). Both inhibit COMT >activity and prolong the duration of effect of each dose of L-DOPA. These >should be launched in 1998.. > > >These drugs are not available in the UK and it looks as if they are still >in trial in the rest of Europe but I am not certain. > > >David Langridge > >The standard dose of Tolcacapone is one pill every six hours Jerry