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The availability of levodopa and the Sinemet combination for treatment of PD is so new, that it shouldn't be difficult to find older people who know what the course of the disease was without these meds. My grandfather and great-uncle both had parkinson's (thought to be caused by the encephalitis of the 1919 flue epidemic). I was only 6 when we visited my grandfather from another state, and my only memory of him was his shaking and inability to move from the rocking chair. He was hospitalized shortly after and died 4 or 5 years later. I was already in Colorado when the great-uncle was diagnosed and know nothing about his disease course except that he also had to be hospitalized when his wife could no longer move him. Do some of you have parents old enough to remember pre-medication days? Miriam L. Denham cg for Dale dx 1988 [log in to unmask]