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I recently joined this list to review it as a support system for my brother(age 59) just diagnosed with PD last May; he has passed through the shock-impact phase and moved on to the realization phase and is very depressed at this point. Since he is on Selegeline and Sinemet, and is in the regulatory drug stage, his neurologist told him that antidepressants are incompatible with the Selegeline. However, as a nurse myself, I feel sure there is some class of antidepressants that can be given to relieve some of his suffering without harmful effects. Can anyone suggest any with this combination? Selegeline(Eldepryl) seems to be the one with the potential drug interaction problem. Thanks in advance. Also, what resources could anyone suggest that were helpful to them on just learning of and trying to cope with a new diagnosis of PD? Maryanne Ludy([log in to unmask]) Jeffery Ludy, M.Ed.,RRT email>[log in to unmask] Clinical Director phone>407-823-2214 University of Central Florida Orlando, Florida