Hi Maryanne Ludy > I recently joined this list to review it as a support system for my > brother(age 59) > ... moved on to the realization phase and is very depressed at this point. It happens to us all. > ... his neurologist told him that antidepressants are incompatible > with the Selegeline. My view is that our bodies have quite enough to cope with in the anti-PD cocktail! What causes depression? Reasons, among others are reduced self-confidence, feelings of failure, too little else to occupy the mind, lack of exercise, and so, physical discomfort. I took up new activities to give me a new focus, and they worked. Helping other PWPs, especially the younger sufferers made me feel worthwhile again, and a totally different new business I could run at my own pace in my enforced retirement. Can you help your brother to find a new interest of his own? Help him to adopt a regular exercise routine - I find it really helps to push myself to the limits from time to time. Good luck & best wishes to you both -- Jeremy Browne, Hampshire, UK [log in to unmask] Shaking Hands BBS, Fidonet 2:252/160 (+44 1252 626233, also FAX)