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hello all, i take 20mg prozac per day; 10mg at breakfast, and 10mg at lunch. i've been taking prozac for 6 years. i believe that i have an inherited tendency to clinical depression [cd] and that this tendency, combined with pd, and a couple of stressful years re my business, all contribute to what i believe is a slight 'tilt' in my chemical makeup. my response to prozac, after trying a couple of other alternatives [non ssri], convinced me that prozac was helping restore the 'tilt' to an almost normal level. [or as 'normal' as i can ever be!] i also take eldepryl: 10 mg per day; 5mg at breakfast, and 5 mg at lunch. i've been taking eldepryl for the same length of time that i've been taking sinemet, i.e. since diagnosis in 1988. i haven't noticed any 'serotonin syndrome' symptoms from the combination of eldepryl and prozac. i know there has been some controversy about the combination of eldepryl and sinemet, but i'm not convinced that the initial studies showing benefits with eldepryl have been disproved yet. i have 'experimented' once or twice, with reducing my eledepryl level, and definitely noticed a worsening of symptoms after a few days. [my symptoms are primarily stiffness and slowness, not tremour] of course, all of the above is what works for me. we all have our own chemical idiosyncracies, and certainly parkinson's qualifies for the disease 'with many faces', no pun intended. janet who still hasn't 'met' another parkie yet. there should be between 100 and 200 here, according to population experts, but they must all be in hiding. [log in to unmask]