Marty, I was put on Bromo (parlodel) when it was still experimental about 4 years ago. At that time I was either on Eldepryl or Artane and made the change under strict supervision over a ten day period at Columbia Pres. Hospital in NYC. Not remembering the exact dates, some short time afterwards I began to think that there were certain forces (no details to be published here) working against me. It was VERY real for me. It became an obsession and somehow I managed to keep it under wraps so noone knew my anxieties. Eventually it surfaced and grew more macabre and the circle of people involved grew. Since my husband was at the center of my paranoia and my target, our lives suddenly turned into trouble. Without relating more unnecessary details my lucky day came when my dear hubby reached his limit and threatened to commit me if I didnt seek "qualified" help. Luckily, my neuro works with a therapist familiar with movement disorders and the related meds etc. IMMEDIATELY, I was hospitalized and started on CLOZORIL. THANK G D FOR THAT DAY.....when my life come bac and our lives came together again. Ive been on Clozoril now for about two years... I realize you all asking how come if the Parlodel caused so much pain I was not removed from it. I can only say that my meds consist of Sinemet 25 + CR 50 + Permax and Parlodel. I ve undergone a Pallidotomy and my PD is now only in my stiff and sometime freezing legs. I am reducing the Parlodel and the CR on a regular ten day rotation and Im down about 30% of pre pallidot. levels. My clozoril will be reduced slowly, I take a total of 3.5 x .25 a day. Choose the best PD neuro you can and work together, be fully tuned to your body and its cycles and response times and if your on Bromo instruct someone close to watch for "strange" behavorial patterns. Good luck to you and dont hesitate to ask anything about PD or related matters here on the list...its the greatest assembleage of PD knowledge ever put together in one spot. Joyce