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Hi Pat Schark > My experience is with pramipexole, a dopamine agonist similar to permax > and parlodel, helper drugs for sinemet.. I've been taking it for 3 and a > half years as part of a drug trial at Washington University in St. Louis. ... > The drug seemed not quite so effective after a while, and I had come to > the conclusion it wasn't doing much of anything until one day I was very > busy and forgot to take it all day, believe it or not. That night I woke > up with a terrible anxiety attack - pains, trembling, heart palpitations > - the whole ball of wax. That made me realize it was having an effect > after all. Hmmmmm - I suspect it may not be quite as simple as that. Most of these drugs which have serious (potential) side-effects also seem to be prone to withdrawal symptoms: thus, while your PD MIGHT not have been benefitting a great deal, your body was accustomed to the intake, and told you loudly about it when discontinued. i do know that Pergolide and Ropinirole both have warnings that you should not discontinue them except under medical guidance! -- Jeremy Browne, Hampshire, UK [log in to unmask] Shaking Hands BBS, Fidonet 2:252/160 (+44 1252 626233, also FAX)