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Tina: As per your request, drug info frm Clinical Pharmacology PLEASE NOTE: Levodopa; Carbidopa/Midazolam Carbidopa-levodopa can cause cardiac arrhythmias if administered before=20 inhalation of hydrocarbon general anesthetics. This interaction is=20 presumably due to the levodopa-induced increases in dopamine.=20 Levodopa-carbidopa should be discontinued 6=978 hours=20 before the administration of general anesthetics. Patient profile for torrance, tina Current 4 medications: =9AAmantadine (Symmetrel=AE) =9ALevodopa; Carbidopa (Sinemet=AE)=7F =9AMidazolam (Versed=AE) =9ASelegiline (Eldepryl=AE) Drug Interactions Report Levodopa; Carbidopa/Amantadine Concomitant administration of amantadine, benztropine, procyclidine, or=20 trihexyphenidyl with levodopa-carbidopa can enhance the therapeutic effec= ts=20 of levodopa but should not be used in patients with a history of psychosi= s. Amantadine can increase the efficiency of levodopa by its action on centr= al=20 nerve terminals. Patients who exhibit psychoses should avoid this=20 combination because of the possibility of an increased psychotic effect. Selegiline/Levodopa; Carbidopa Administration of levodopa to patients receiving drugs that inhibit=20 monoamine oxidase (MAO) can produce a hypertensive response. While=20 traditional MAOIs such as phenelzine inhibit MAO type A and selegiline is= =20 selective for MAO type B, at doses above 30=9740 mg/day, this selectivity is lost. Selegiline can increase levodopa-induced dyskinesias, nausea,=20 orthostatic hypotension, confusion, and hallucinations. Reductions in=20 levodopa dosage may be necessary within a few days after the start of=20 selegiline treatment. Even though Parkinson's disease is an indication fo= r both selegiline and levodopa, and these 2 drugs are administered together= =20 safely in some cases, patients should be monitored closely for hypertensi= ve=20 responses, especially if selegiline doses higher than 10 mg/day are used.= It=20 is likely, however, that combining selegiline with levodopa-containing=20 products for the treatment of Parkinson's disease may decline due=20 to a report of higher mortality with combination therapy compared to ther= apy=20 with levodopa without selegiline.=CA=CA=D0=D2 Concomitant use of monoamine oxidase inhibitors (MAOIs) with=20 levodopa-carbidopa can result in hypertensive crisis. Simultaneous use of= =20 these agents is contraindicated. MAOIs should be discontinued 2=974 weeks= =20 before initiation of levodopa-carbidopa therapy. Although selegiline inhibits MOA type B, the adverse effects associated with levodopa, includ= ing orthostatic hypotension, confusion, dyskinesias, nausea, and hallucinatio= ns,=20 can be exacerbated by concomitant administration of selegiline. Dosages o= f=20 levodopa should be reduced within 2=973 days after beginning selegiline=20 therapy. Additive Adverse Reactions Report 3 of these drugs may cause: =95anorexia (amantadine; levodopa/carbidopa; selegiline) =95nausea/vomiting (amantadine; levodopa/carbidopa; selegiline) =95orthostatic hypotension (amantadine; levodopa/carbidopa; selegiline) 2 of these drugs may cause: =95agitation (amantadine; selegiline) =95anxiety (amantadine; selegiline) =95ataxia (amantadine; levodopa/carbidopa) =95confusion (amantadine; selegiline) =95constipation (amantadine; selegiline) =95depression (amantadine; selegiline) =95diarrhea (amantadine; selegiline) =95dizziness (amantadine; selegiline) =95drowsiness (amantadine; selegiline) =95dystonia (levodopa/carbidopa; selegiline) =95hallucinations (amantadine; selegiline) =95headache (amantadine; selegiline) =95hypertension (levodopa/carbidopa; selegiline) =95insomnia (amantadine; selegiline) =95neuroleptic malignant syndrome (amantadine; levodopa/carbidopa)=7F =95urinary retention (levodopa/carbidopa; selegiline) =95weight loss (levodopa/carbidopa; selegiline) =95xerostomia (amantadine; selegiline) Drugs/Contraindications Warning No potential drug/contraindication warnings were identified. I wish you good luck. >i am to have a medical proceedure early tomorrow morning. > >the doctor will give me a mild sedative,called FENFANYL >and/or VERSED. > >can anyone tell me if these drugs will interact with my, >PD meds. I take SINEMET 25/100, ELDEPRYL 5MG,3 AMANTADINE. Regards, Margaret Tuchman (54 yrs, dx 1980) ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ I've got Parkinson's disease. And he's got mine.