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Joe, I can't speak from much experience - I've had PD since 93, been on eldepryl and sinemet most of the time, gradually decreasing the eldepryl and increasing the sinemet (as of today, I take one 5 mg eldepryl and 5-6 25/100 sinemet a day. The stiffness/pain/aches in the upper arms, I too have. I attribute some, if not all, to the rigidity I have - for example, I notice that when I drive, I often notice that I have a STRONG grip on the steering wheel, which means tense arm muscles. I also have aches in my thighs - I try to do daily stretching exercises, both for the legs and some power bacl problems I've had for 20 years. Anybody else have any suggestions about this - what seems to help? mark hardy email.grafenwoehr.army.mil