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Dear Dianne; your list is in my opinion, the biggest bunch of baloney ever seen in a medical board. as an 8 year user i have experienced of course, occasionally, some of the effect mentioned, but overall , it seems to have slowed down pd to the point that i can still , at 61, do all physical activities i did before, including rough tennis matches, cementing the driveway, gardening moving tons of earth, pickup 2 or 3 of my five granchildren at a time, walk/run the dog 3 times daily, etc.......rigidity only under stress, like when i see such a ''scary'' list.... thank goodness you do not use it.