Hi, Joe, welcome to the best thing that's happened to me in months -- the Parkinson Mail list. I have found it invaluable, allthough my husband's neurologist views it with a jaundiced eye. (tough!) My husband has been on Sinemet for almost 20 years; he was diagnosed in 1972. The important thing to remember is that the disease progresses at a different rate in everyone; there's no rule of thumb. Also, you may be more sensitive to some meds than to others. Eldepryl didn't work for him, although when it came out he was not newly diagnosed and that's the group Eldepryl is more recommended for. A lot of it is trial and error, unfortunately. Dave (spouse) also experienced pain in legs and feet; muscle cramps are common. He no longer has those. To George Lussier -- lots of good luck with your second side! We hereby grant you the right to bitch and moan for TWENTY minutes a day, should you so desire. You are entitled! When we considered pallidotomy for my husband, his reaction was NOONE'S DOING BRAIN SURGERY ON ME! Fortunately or unfortunately, he was not a candidate anyhow, because after cognitive testing, it was determined he would not handle the surgery successfully. As a caregiver, I am really too busy to feel sorry for myself, even privately. And with this new Mail list I feel there's a lot of sympathy out there! Re: Humor -- it helps! We had an appointment with Dave's neurologist Friday, and Dave's drooling almost drowned everyone in the office. Finally the neurologist has an appreciation of the unaesthetic problem - it may not be painful or life-threatening, but I assure you it's a dam nuisance! Ok, that's my complaining for today. Permitted? My daughter-in-law suggested that the drooling is caused by atrophying of the throat muscles; swallowing is difficult. She learned that at a Parkinson's support group. Sounds better than the neurologist's theory, which I won't go into. I'm wondering whether some sort of oral exercises would help. Sorry this is so long. Feel free to delete me! Naomi Meyer CG Dave 68/24 [log in to unmask]