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Greetings, I'm wondering if anyone has experienced an "off" day similar to the one I will describe. Last Saturday, I had a tremor virtually all day. It was as if the medication I was taking contained no anti-parkinson properties. I've had off-periods before, but they only lasted for a few hours and then the medication finally kicked in. But Saturday was a non-stop tremor day. The only thing I can think of is that I probably didn't drink as much water with the pills as I ordinarily do. My daily regimen is as follows: 3 or 4 sinemet 25/100; 3 sinemet 50/200 CR; 2.5 mg. permax; and, 3 amantadine (100 mg.). Any comments or observations will be appreciated. George L. Bousliman (age 55; diagnosed in 1989; left side thalamotomy in 1991) Helena, Montana