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Helen - 80/5PD - main symptoms are excessive tremor, which has deteriorated over the years. Present PD medication is:- 3 - 5mg/day Procyclidine & occassionally half tablet 62.5 mg Madopar Dispersible which she is taking to try and accustomise herself to L-Dopa, which she feels she needs, but which only accentuates the tremor and causes considerable agitation.. Initially she tried Disipal, which almost cured the tremor, but caused considerable nausea, and the tremor returned as before. We are now discussing alternastive medications with her doctor and the following are being considered: 1. Revert back to Disipal, but with an anti-nausia drug, such as domaperidone. 2. Pergolide/Permax 3. Ropininole/Requip. (1) Causes us concern, as it means taking a fairly powerful drug to counter the effect of another drug, and this seems a slipperly slope if there are alternatives. (2) There have been some very worrying accounts on the List of the severe side effects e.g. halucinations etc. of Peroglide/Permax. (3) Appeals to me - I'm a sucker for anything new - but our doctor has no direct experience of Ropinole, and is reluctant to prescribe it, but several postings have suggested that it has many lower side effects than Pergolide. Has any one the list any direct experience of either pergolide or ropinole on tremor, which seems to be one of the most difficult symptomx of PD to allievate. with best wishes to you all Ray ([log in to unmask])