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>(Might add that I am also very sensitive to the ingredients in >decongestants/antihistimes what have you that promote drowsiness.......most >would give me a very wonderful 12 or 14 hours of sleeep........unfortunately >during the work day in some instances! Perhaps there is a correlation >between that and the carbidopa impact on some individuals.) > >Rita **************************************************************************** ****************** IMOHO, I don't think it's the Sinemet. I experienced the same sensitivity to antihistimes you described. Way before my symptoms had a name, I suddenly couldn't take ANY antihistimes anymore---the kept me AWAKE for days & nights on end & worse than that, I couldn't stand up!!! I have allergic asthma (which I didn't get till I was 33 years old), & suddenly antihistimines I had taken for years, I couldn't tolerate anymore. My allergist & I tried them all---Seldane, Claritin, etc.. Still couldn't stand up, to say nothing of walking!!! Finally we settled on Inhaled Steriods with 20 tables of 20 mg. Cortisone to be carried in my purse for backup. So far, 4 years later I seem to be able to keep the asthma under control, but have only been taking Sinemet for 3 years so I don't think it's the Sinemet!!! I think it's the PD. As Ever, Marjorie Moorefield just another librarian (with PD)