On 6 OCT 96 Will A Kulpers writes <Anyhow, maybe because of the CR I never experienced "on" or "off" conditions. < <but it makes me sometimes wonder why I take these meds. <I have no problems walking, but my voice is affected. < <I wonder if there are more people with no clear on or off symptons, either due <to the meds <or due to the fact that their PD has not progressed very far. Hi Will, Sorry to be so late in answering. Add me to your list right away. I am 68 and PD was diagnosed 9 years ago. Initially, my speech and handwriting, coupled with a tendency of my eyes to close, were the main problems. More recently I have been experiencing problems with my balance and also with my walking. And never a twitch nor a feeling of normality and well-being to show for it! Like you I sometimes wondered why I took the Sinemet but now know when a dose is due. Instead of feeling "off" I realise that I am quite unable to open my eyes to see this wretched video screen. So I suppose that that is how I register being "off". If I do manage to open my eyes and if I get up then I shall probably lose my balance and fall over more readily. It wasn't so easy recognising the "off" signals in the early days. But they were there all right. A pronounced tingling sensation in my left forearm was most useful in finding the minimum dose of Sinemet. Does anybody else have "off" and "on" recognition problems? JACK TIBBS [log in to unmask]