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I've been participating in the pramipexole study at WashU, yet have been=20 experiencing increasing disability: insomnia, distonia, incrased "off"=20 periods and more dyskinesia. Had my three month appointment last=20 Wednesday and received enough medication to last until my next visit in=20 the form of six bottles: two each marked 1, 2, and 3. Since this was=20 never done before, I mistakenly matched a 1 and a 2, meaning in effect=20 that I was getting two doses of the stronger medication instead of a=20 combo of the strong and weaker. I didn't discover it until today, almost= =20 a week later. The only thing I'd noticed is that I was suddenly much=20 better: I slept well at night, had no distonia, experienced=20 practically no off periods or dyskinesia, and could get by with less=20 sinement.. The obvious conclusion is that=20 I've been undermedicated all along and need to increase the pramipexole. Alas, because I'm part of a research study, I can't make any changes in=20 the protocol until the drug is marketed, which may not be for another=20 year or so. This seems inhumane to say the least, since my symptoms are=20 seriously interfering with my life. It is, of course, a Catch 22=20 situation because if I quit the study to continue with the stronge dosage= =20 I won't be able to get the medicine anymore. Does anyone have a resolution to thi=D53=D5[a=C6^=C3=DBX]=D3 It would seem = to me that=20 the fact that increasing my dosage had such a positive impact on my=20 symptoms would be valuable info for the study. Instead, it must be=20 ignored and I have to go back to being disabled. That strikes me as=20 inhumane to say the least.. pine`