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Hi Camilla and Ron Your postings are most interesting I would like to add my 2 cents to the 'Carbidopa question'. I have no 'evidence' other than personal experience. I do think there is some truth in the suggestion that, for some PWP, a large intake of Carbidopa can cause trouble ( There arethree weasels in that sentence!!). In the summer of 1995 my Sinemet was increased and I began to notice quick changes in mood, unexpected and sudden OFF times and a feeling of being at the mercy of the pills. With the encouragement of Alan Bonander and my neurologist I slowly decreased the amount of Carbidopa taken each day by substituting the 100/10 and 250/25 formats of Sinemet for CR and 100/25. When the Carbidopa was reduced I began to feel more rational and the sudden OFF spells were few and far between. The report I did, with all the numbers, is buried in my old files --but I could dig it out. I have stayed on the 1 to 10 ratio since then. I take 1,000 mg Levodopa &100 mg Carbidopa in Sinemet as well as 5mg Permax. I take approximately the same amount every 3 hours --round the clock. (less at night).(dx 1980 / now 62yrs) However I can't use my present state as evidence because of a Pallidotomy in April 96. Anne Rutherford << [log in to unmask]>>