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I'm sorry that I deleted the question about joint pain, so you'll just have to know if this is for you. I have Osteoarthritis, in fact, Osteoarthritis and PD are both listed in my Americans with Disabilities Form. I found out that when I took a whole 25/100 Sinemet, within the hour I would feel the Osteoarthritis pain in my neck, vertebrates 5 & 7 really need to be replaced, but I'm not in the mood!!! So after about a week of this, I decided to break the Sinemet in half before I took them--Wonder of all wonders---it worked. Now I never take a whole tablet at once. Check with your Doctor before doing this, but had I checked with mine, he would have said "Surgery Time" and I'm still suffering from my perforated colon surgery--Thank You very Much!!!!! In my own mind, I decided that it was just too much of a jolt to my already overstressed frame!! Only God knows if this is true, but it worked for me!!! As Ever, Marjorie Moorefield just another librarian (with PD)