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Hello, Last week I subscribed to the Parkinson list. My name is Susanna Bicknell, from Nijmegen in the Netherlands, I am 25 years old and the youngest daughter of David Bicknell, an Englishman living in the Netherlands, who is 57 years old and was diagnosed with Parkinson in 1992, he thinks he has had Parkinson since 1989-1990. We think that his Parkinson is very progressive. His medication is: Madopar HBS 125 mg, six a day Madopar COMB 100/25 mg, six a day Permax 0,25 mg, 12 a day Symptoms: (Brady)=slowness (kinesia) in moving. Brady kinesia: Right arm does not swing when walking, freezing, start problems, problems turning in bed, right side of the body is affected (Brady kinesia). Dystonia = Right hand tented, turned in foot, incontrollable tightening of muscles, Dyskinesia. Tremor in right arm and hand under stress. The symptoms which I described have been given to me by my father for my information. The way in which I see the symptoms is: During the day everything seems quite allright, except for some moments. But in the evening from about 7.30 p.m. he cannot do anything anymore, he cannot move anymore, and the way in which he describes how he feels is that he has a lot of pain. His head and right sholder are pushed down. For my mother and father it is very frightening in the evenings, because my father has the idea when this is happening that he is going to die, because he has all this pain and it seems more difficult to breath. Sometimes he cannot go to bed and sleeps downstairs. I would like to know what you think about the amount of medication, because it seems that everytime he talks to the doctor about how everything is going he gets more tablets, and the tablets do not seem to help. I know that every person having Parkinson's is different, but could anybody give me an idea, if the amount of medication is high, and if you think that the way I described my fathers Parkinson's is progressive? Greetings and thanks for any help. Susanna Bicknell ( [log in to unmask] ) Nijmegen, the Netherlands