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I have been diagnosed for over 5 years and at about stage III taking a substantial amount of sinemet to keep going (along with parlodel). Up until recently, I was able to get a reasonable amount of energy up when medicated. I just returned from a marvelous trip to Israel where I had a good time. did and saw everything and walked more than usual. Needless to say, the plane ride was interminable and tiring. I've been back for a week now and am always tired, my off periods seem worse than usual and I'm convinced that I'm getting closer to the vegetable bin. My wife tells me I'm probably suffering the effects of fatigue and that it might take several weeks to recover. I never experienced anything like this before and last month my various physicians (non neuro) did my annual exam and work-up and pronounced me well. Before I start crying to my high priced neuro, I thought I would ask if anyone has had a similar experience.