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A number of listmembers have recently mentioned loss or impairment of smell (me too). When I told my neuro he brushed it off as trivial. I worked on autos for many years, and noticed that gasoline fumes temporarily deaden tne sense of smell. The problem with any symptom for diagnosis is that it is subjective and not quantitative. Researchers would like to find an unambiguous positive marker that does not require judgement by the patient. It's most important for clinical trials where inclusion of subjects who don't really have PD can cause misleading results. Presently we don't even know if the various forms of PD are all the same disease, or not. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Sat, 2 Nov 1996, Dick Swindler wrote: > I have been told that smell is an accurate diagnosis for PD. In fact, the > administration of a smell test is some 80% accurate in predicting PD. Also, > if you combine this test with one on hand-eye coordination it jumps the rate > up to 90%. Has anybody heard of this . >