Dear friends on the listserv, I am one of the people taking the experimental drug "ENTACAPONE" produced by Orion Pharma of Espoo, Finland - probably to be marketed by Sandoz. ENTACAPONE is a COMT inhibitor which I understand does not cross the blood/brain barrier, but protects the levodopa in Sinemet from attack by forces in the torso, much like carbidopa but against a different predator. I have seen a good bit of traffic among the 'Prammy' users, but about nothing from Entacapone users. Are there any other Entacapone users out there? WILL JOHNSTON 4049 OAKLAND SCHOOL ROAD SALISBURY, MD 21804-2716 410-543-0110 Pres A.P.D.A. DelMarVa Chapter 63 Dx1991 Symptoms 1971 ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ + + + Repeal the 23rd Amendment before 2000 + + + ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++