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At 11:49 03/11/96 -0500, will johnston wrote: >I am one of the people taking the experimental drug "ENTACAPONE" produced by >Orion Pharma of Espoo, Finland - probably to be marketed by Sandoz. > >ENTACAPONE is a COMT inhibitor which I understand does not cross the >blood/brain barrier, but protects the levodopa in Sinemet from attack by >forces in the torso, much like carbidopa but against a different predator. > >I have seen a good bit of traffic among the 'Prammy' users, but about >nothing from Entacapone users. Are there any other Entacapone users out there? Hello Will, I'm not a user yet, but I am going to take part in a drug study using Tolcapone, which is also a COMT inhibitor, and is expected to be marketed in the new year. The study that I will be involved in is to determine the quantity of the drug that produces the best results. A Parkinson's specialist mentioned both Tolcapone and Entacapone in a lecture about new drugs, so they are probably similar, if not identical. I hope you and I can compare results as we go along. Judith